Universal transcriptomic hallmarks of mammalian ageing and mortality - Nature

Researchers integrated gene-expression data from multiple tissues across four mammalian species and identified conserved transcriptomic signatures linked to ageing and mortality. They organized these signatures into a modular architecture of ageing and mortality hallmarks, highlighting shared pathways across tissues and species. These conserved molecular patterns can help connect tissue-specific mechanisms — for example, inflammation and metabolic changes implicated in gut–brain studies — to broader, cross-species ageing programs.