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RNA-triggered cell killing with CRISPR–Cas12a2 - Nature
Overview
Researchers describe Cas12a2, a CRISPR enzyme that is activated by specific RNA sequences to trigger widespread DNA shredding and kill eukaryotic cells. This mechanism enables sequence-specific elimination of cells based on their gene expression, including virus-infected or mutation-bearing cells. The approach could be used to selectively remove harmful cells in settings such as viral infection or cancer, though practical use will require solutions for delivery, specificity in complex tissues, and safety testing.
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